Amitriptyline is used for treating depression.
Amitriptyline price per pill with an estimated street value was $1.60 in the third quarter of 2015, and $1.50 in the fourth quarter, according to Truven Health Analytics.
AstraZeneca said in a statement its pricing "reflects the significant risks for a new and untested medication, while supporting its regulatory approval to treat schizophrenia," and the company will work with FDA to "ensure appropriate pricing."
On Tuesday, the Wall Street Journal reported that AstraZeneca's pricing may have been affected by higher than expected generic drug costs.
The company has previously said a new anti-psychotic drug to treat schizophrenia and bipolar disorder — Seroquel was delayed because of costs but has also said its prices were competitive with generic versions